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Article

Genome-wide DNA methylation profiles in hepatocellular carcinoma

11 Jan 2012

Abstract excerpt

UNLABELLED: Alterations in DNA methylation frequently occur in hepatocellular cancer (HCC). We have previously demonstrated that hypermethylation in candidate genes can be detected in plasma DNA before HCC diagnosis. To identify, with a genome-wide approach, additional genes hypermethylated in HCC that could be used for more accurate analysis of plasma DNA for early diagnosis, we analyzed tumor and adjacent...

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PMID: 22234943
DOI: 10.1002/hep.25569

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