Article
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
Human molecular genetics - 1 Jun 2014
Stacey Simon N, Sulem Patrick, Gudbjartsson Daniel F, Jonasdottir Aslaug, Thorleifsson Gudmar, Gudjonsson Sigurjon A, Masson Gisli, Gudmundsson Julius, Sigurgeirsson Bardur, Benediktsdottir Kristrun R, Thorisdottir Kristin, Ragnarsson Rafn, Fuentelsaz Victoria, Corredera Cristina, Grasa Matilde, Planelles Dolores, Sanmartin Onofre, Rudnai Peter, Gurzau Eugene, Koppova Kvetoslava, Hemminki Kari, Nexø Bjørn A, Tjønneland Anne, Overvad Kim, Johannsdottir Hrefna, Helgadottir Hafdis T, Thorsteinsdottir Unnur, Kong Augustine, Vogel Ulla, Kumar Rajiv, Nagore Eduardo, Mayordomo José I, Rafnar Thorunn, Olafsson Jon H, Stefansson Kari
Abstract excerpt
To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide association study of 38.5 million single nucleotide polymorphisms (SNPs) and small indels identified through whole-genome sequencing of 2230 Icelanders. We imputed genotypes for 4208 BCC patients and 109 408 controls using Illumina SNP chip typing data, carried out association tests and...
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