Article
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
Nature genetics - 1 Nov 2008
Stacey Simon N, Gudbjartsson Daniel F, Sulem Patrick, Bergthorsson Jon T, Kumar Rajiv, Thorleifsson Gudmar, Sigurdsson Asgeir, Jakobsdottir Margret, Sigurgeirsson Bardur, Benediktsdottir Kristrun R, Thorisdottir Kristin, Ragnarsson Rafn, Scherer Dominique, Rudnai Peter, Gurzau Eugene, Koppova Kvetoslava, Höiom Veronica, Botella-Estrada Rafael, Soriano Virtudes, Juberías Pablo, Grasa Matilde, Carapeto Francisco J, Tabuenca Pilar, Gilaberte Yolanda, Gudmundsson Julius, Thorlacius Steinunn, Helgason Agnar, Thorlacius Theodora, Jonasdottir Aslaug, Blondal Thorarinn, Gudjonsson Sigurjon A, Jonsson Gudbjörn F, Saemundsdottir Jona, Kristjansson Kristleifur, Bjornsdottir Gyda, Sveinsdottir Steinunn G, Mouy Magali, Geller Frank, Nagore Eduardo, Mayordomo José I, Hansson Johan, Rafnar Thorunn, Kong Augustine, Olafsson Jon H, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide SNP association study of 930 Icelanders with BCC and 33,117 controls. After analyzing 304,083 SNPs, we observed signals from loci at 1p36 and 1q42, and replicated these associations in additional sample sets from Iceland and Eastern Europe. Overall, the most significant signals were from...
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