Site-specific mutagenesis of AIDS virus reverse transcriptase.

doi:10.1038/327716a0

Back to search

Article

Site-specific mutagenesis of AIDS virus reverse transcriptase.

Nature - 1 Jan 2000

Larder B A, Purifoy D J, Powell K L, Darby G

Abstract excerpt

Human immunodeficiency virus (HIV) is the causative agent of AIDS (acquired immune deficiency syndrome) a disease which poses a serious challenge to modern medicine. If we are to conquer this disease we will need a protective vaccine or effective drugs able to block the life cycle of the virus. A...

Topics

Amino Acid Sequence
DNA, Viral
Escherichia coli
Foscarnet
HIV
Mutation
Phosphonoacetic Acid
RNA-Directed DNA Polymerase
Reverse Transcriptase Inhibitors
Structure-Activity Relationship
Thymidine
Zidovudine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.