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Article

Site-specific mutagenesis of AIDS virus reverse transcriptase.

Nature - 1 Jan 2000

Larder B A, Purifoy D J, Powell K L, Darby G

Abstract excerpt

Human immunodeficiency virus (HIV) is the causative agent of AIDS (acquired immune deficiency syndrome) a disease which poses a serious challenge to modern medicine. If we are to conquer this disease we will need a protective vaccine or effective drugs able to block the life cycle of the virus. An early stage in the invasion of the host cell is the conversion of the RNA genome of the virus to a double-stranded...

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Source

Identifiers

PMID: 2439916
DOI: 10.1038/327716a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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