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Article

Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis.

Journal of virology - 1 May 1992

Hostomsky Z, Hostomska Z, Fu T B, Taylor J

Abstract excerpt

From an in vitro analysis of the DNA-synthesizing abilities of certain specifically mutated forms of the heterodimeric reverse transcriptase of human immunodeficiency virus type 1, we can conclude that in a heterodimer, the functionality of p66 is necessary while the functionality of the p51 subunit is not needed. Conversely, p51 is not able to catalyze DNA synthesis when associated with p66, and yet when the p66...

Topics

Acquired Immunodeficiency Syndrome
Cloning, Molecular
DNA Mutational Analysis
DNA, Viral
Genes, pol
HIV-1
Humans
Mutation
RNA-Directed DNA Polymerase

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1373206
DOI: 10.1128/JVI.66.5.3179-3182.1992
PMCID: PMC241083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1373206-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis.PMID 1373206Read ↗

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