Article
Genetic selection in Escherichia coli for active human immunodeficiency virus reverse transcriptase mutants.
Methods (San Diego, Calif.) - 1 Aug 1997
Kim B
Abstract excerpt
Most catalytically active human immunodeficiency virus (HIV) reverse transcriptase (RT) mutants characterized to date have been isolated from the virus after treatment with HIV RT inhibitors such as nucleoside analogs. However, detailed understanding of structure-function relationships, and of the roles of the several catalytic activities of HIV RT in viral replication, requires characterization of a greater...
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