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Article

Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1993

Martin J L, Wilson J E, Haynes R L, Furman P A

Abstract excerpt

A molecular clone containing the wild-type reverse transcriptase (RT) coding region of human immunodeficiency virus type 1 (HIV-1) was constructed, and site-directed mutagenesis was used to introduce mutations--Leu74-->Val (L74V), T215Y, and the combination L74V/T215Y--into the RT coding region. The proteins were purified by immunoaffinity chromatography. Assays were performed with mutant and wild-type RT to...

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Identifiers

PMID: 7687061
DOI: 10.1073/pnas.90.13.6135
PMCID: PMC46882

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Source receipt: pubmed, retrieved 7 Sept 2026.

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