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Article

Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1993

Martin J L, Wilson J E, Haynes R L, Furman P A

Abstract excerpt

A molecular clone containing the wild-type reverse transcriptase (RT) coding region of human immunodeficiency virus type 1 (HIV-1) was constructed, and site-directed mutagenesis was used to introduce mutations--Leu74-->Val (L74V), T215Y, and the combination L74V/T215Y--into the RT coding region. The proteins were purified by immunoaffinity chromatography. Assays were performed with mutant and wild-type RT to...

Topics

Base Sequence
Cloning, Molecular
Deoxyribonucleotides
Didanosine
Drug Resistance, Microbial
HIV Reverse Transcriptase
HIV-1
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
RNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reverse Transcriptase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 7687061
DOI: 10.1073/pnas.90.13.6135
PMCID: PMC46882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7687061-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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