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Article

Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings.

Gut - 1 Oct 2014

Hedin Charlotte R, McCarthy Neil E, Louis Petra, Farquharson Freda M, McCartney Sara, Taylor Kirstin, Prescott Natalie J, Murrells Trevor, Stagg Andrew J, Whelan Kevin, Lindsay James O

Abstract excerpt

OBJECTIVE: Crohn's disease (CD) is associated with intestinal dysbiosis, altered blood T cell populations, elevated faecal calprotectin (FC) and increased intestinal permeability (IP). CD-associated features present in siblings (increased risk of CD) but not in healthy controls, provide insight into early CD pathogenesis. We aimed to (1) Delineate the genetic, immune and microbiological profile of patients with...

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Identifiers

PMID: 24398881
DOI: 10.1136/gutjnl-2013-306226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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