Article
Family studies in Crohn's disease: new horizons in understanding disease pathogenesis, risk and prevention.
Gut - 1 Feb 2012
Hedin Charlotte R, Stagg Andrew J, Whelan Kevin, Lindsay James O
Abstract excerpt
Crohn's disease (CD) is an incurable intestinal disorder in which the loss of immune tolerance to the commensal gut microbiota leads to chronic inflammation. The reason this occurs in specific individuals is unclear; however, a genetic predisposition is fundamental and relatives of patients with CD are at significant risk of developing the disease. Knowledge relating to the genetic loci that predispose to CD is...
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