Article
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.
Gut - 1 Jan 2018
Imhann Floris, Vich Vila Arnau, Bonder Marc Jan, Fu Jingyuan, Gevers Dirk, Visschedijk Marijn C, Spekhorst Lieke M, Alberts Rudi, Franke Lude, van Dullemen Hendrik M, Ter Steege Rinze W F, Huttenhower Curtis, Dijkstra Gerard, Xavier Ramnik J, Festen Eleonora A M, Wijmenga Cisca, Zhernakova Alexandra, Weersma Rinse K
Abstract excerpt
OBJECTIVE: Patients with IBD display substantial heterogeneity in clinical characteristics. We hypothesise that individual differences in the complex interaction of the host genome and the gut microbiota can explain the onset and the heterogeneous presentation of IBD. Therefore, we performed a case-control analysis of the gut microbiota, the host genome and the clinical phenotypes of IBD. DESIGN: Stool samples,...
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