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Article

Siblings of patients with Crohn's disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities.

Gut - 1 Jun 2016

Hedin Charlotte, van der Gast Christopher J, Rogers Geraint B, Cuthbertson Leah, McCartney Sara, Stagg Andrew J, Lindsay James O, Whelan Kevin

Abstract excerpt

OBJECTIVE: To determine the existence of mucosal dysbiosis in siblings of patients with Crohn's disease (CD) using 454 pyrosequencing and to comprehensively characterise and determine the influence of genotypical and phenotypical factors, on that dysbiosis. Siblings of patients with CD have elevated risk of developing CD and display aspects of disease phenotype, including faecal dysbiosis. Whether the mucosal...

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Identifiers

PMID: 25856344
DOI: 10.1136/gutjnl-2014-308896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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