Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk.

doi:10.1053/j.gastro.2021.07.009

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Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk.

Gastroenterology - 1 Nov 2021

Lee Sun-Ho, Turpin Williams, Espin-Garcia Osvaldo, Raygoza Garay Juan Antonio, Smith Michelle I, Leibovitzh Haim, Goethel Ashleigh, Turner Dan, Mack David, Deslandres Colette, Cino Maria, Aumais Guy, Panaccione Remo, Jacobson Kevan, Bitton Alain, Steinhart A Hillary, Huynh Hien Q, Princen Fred, Moayyedi Paul, Griffiths Anne M, Silverberg Mark S, Paterson Andrew D, Xu Wei, Croitoru Kenneth

Abstract excerpt

BACKGROUND AND AIMS: Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn's disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDRs) of CD patients is an independent risk factor for future CD development. METHODS: We measured host serum antibody response to 6 microbial antigens at...

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PMID: 34293299
DOI: 10.1053/j.gastro.2021.07.009

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