Article
Variation of Gut Mucosal Microbiome With Anti‐Saccharomyces cerevisiae Antibody Status in Pediatric Crohn Disease
8 Aug 2019
Abstract excerpt
OBJECTIVES: Crohn disease (CD) is a chronic relapsing condition possibly caused by a dysbiotic microbiome. Approximately 30% to 60% of patients with CD have anti-Saccharomyces cerevisiae antibody (ASCA), but any association with gut microbiota is unexplored. We hypothesized that ASCA positivity would predict a signature microbial status and clinical phenotype. METHODS: Ileocolonic mucosal biopsies were obtained...
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