Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease.

doi:10.1053/j.gastro.2024.08.031

Article

Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease.

Gastroenterology - 1 Jan 2025

Olivera Pablo A, Martinez-Lozano Helena, Leibovitzh Haim, Xue Mingyue, Neustaeter Anna, Espin-Garcia Osvaldo, Xu Wei, Madsen Karen L, Guttman David S, Bernstein Charles N, Yerushalmi Baruch, Hyams Jeffrey S, Abreu Maria T, Marshall John K, Wrobel Iwona, Mack David R, Jacobson Kevan, Bitton Alain, Aumais Guy, Panacionne Remo, Dieleman Levinus A, Silverberg Mark S, Steinhart A Hillary, Moayyedi Paul, Turner Dan, Griffiths Anne M, Turpin Williams, Lee Sun-Ho, Croitoru Kenneth

Abstract excerpt

BACKGROUND & AIMS: Unaffected first-degree relatives (FDRs) from families with ≥2 affected FDRs with Crohn's disease (CD, multiplex families) have a high risk of developing CD, although the underlying mechanisms driving this risk are poorly understood. We aimed to identify differences in biomarkers between FDRs from multiplex vs simplex families and investigate the risk of future CD onset accounting for potential...

Topics

Join the communities discussing this publication.

Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease.

Abstract excerpt

Topics

Discuss the evidence

Related research