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Article

A novel murine model of early calcium pyrophosphate deposition disease based on the TNFRSF11B mutation mimics features of the human disease.

Annals of the rheumatic diseases - 1 Aug 2026

Wang Chun, Gohr Claudia M, Mitton-Fitzgerald Elizabeth, Oestreich Arin K, Li Yongjia, Xiao Jianqiu, Kaur Khushpreet, Guilak Farshid, Veis Deborah J, Rosenthal Ann K, Mbalaviele Gabriel

Abstract excerpt

OBJECTIVES: Calcium pyrophosphate deposition (CPPD) disease is a common form of arthritis affecting older individuals. This disease is characterised by high levels of pyrophosphate in articular cartilage, resulting in calcium pyrophosphate crystal formation in humans and inflammatory and degenerative arthritis. A loss-of-function mutation in the TNFRSF11B locus (also known as CCAL1), which encodes osteoprotegerin...

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Identifiers

PMID: 41826214
DOI: 10.1016/j.ard.2026.02.014

Genes

TNFRSF11B
ENPP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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