Article
SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014
Lilley Brendan N, Krishnaswamy Arjun, Wang Zhi, Kishi Masashi, Frank Eric, Sanes Joshua R
Abstract excerpt
Axons develop in a series of steps, beginning with specification, outgrowth, and arborization, and terminating with formation and maturation of presynaptic specializations. We found previously that the SAD-A and SAD-B kinases are required for axon specification and arborization in subsets of mouse neurons. Here, we show that following these steps, SAD kinases become localized to synaptic sites and are required...
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