Article
A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation.
Neural development - 22 Sept 2008
Kim Joanne S M, Lilley Brendan N, Zhang Chao, Shokat Kevan M, Sanes Joshua R, Zhen Mei
Abstract excerpt
BACKGROUND: Neurons assemble into a functional network through a sequence of developmental processes including neuronal polarization and synapse formation. In Caenorhabditis elegans, the serine/threonine SAD-1 kinase is essential for proper neuronal polarity and synaptic organization. To determine if SAD-1 activity regulates the establishment or maintenance of these neuronal structures, we examined its temporal...
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