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Article

C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.

Development (Cambridge, England) - 1 Jan 2010

Kim Joanne S M, Hung Wesley, Narbonne Patrick, Roy Richard, Zhen Mei

Abstract excerpt

Neurons are polarized cells with morphologically and functionally distinct axons and dendrites. The SAD kinases are crucial for establishing the axon-dendrite identity across species. Previous studies suggest that a tumour suppressor kinase, LKB1, in the presence of a pseudokinase, STRADalpha, initiates axonal differentiation and growth through activating the SAD kinases in vertebrate neurons. STRADalpha was...

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PMID: 20023164
DOI: 10.1242/dev.041459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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