Article
Mutant TP53 posttranslational modifications: challenges and opportunities.
Human mutation - 1 Jun 2014
Nguyen Thuy-Ai, Menendez Daniel, Resnick Michael A, Anderson Carl W
Abstract excerpt
The wild-type (WT) human p53 (TP53) tumor suppressor can be posttranslationally modified at over 60 of its 393 residues. These modifications contribute to changes in TP53 stability and in its activity as a transcription factor in response to a wide variety of intrinsic and extrinsic stresses in part through regulation of protein-protein and protein-DNA interactions. The TP53 gene frequently is mutated in cancers,...
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