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Article

The thyroid hormone receptor β induces DNA damage and premature senescence

6 Jan 2014

Abstract excerpt

There is increasing evidence that the thyroid hormone (TH) receptors (THRs) can play a role in aging, cancer and degenerative diseases. In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice. T3 induces a rapid activation of ATM (ataxia telangiectasia mutated)/PRKAA...

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PMID: 24395638
DOI: 10.1083/jcb.201305084

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