Article
TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.
Cellular signalling - 1 Dec 2014
Kretova Miroslava, Sabova Ludmila, Hodny Zdenek, Bartek Jiri, Kollarovic Gabriel, Nelson Buck D, Hubackova Sona, Luciakova Katarina
Abstract excerpt
Oxidative stress and persistent activation of DNA damage response (DDR) are causally involved in the development of cellular senescence, a phenomenon implicated in fundamental (patho)physiological processes such as aging, fetal development and tumorigenesis. Here, we report that adenine nucleotide translocase-2 (ANT2) is consistently down-regulated in all three major forms of cellular senescence: replicative,...
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