Article
A novel role for thyroid hormone receptor beta in cellular radiosensitivity.
Journal of radiation research - 1 Jan 2008
Matsuse Michiko, Saenko Vladimir, Sedliarou Ilya, Rogounovitch Tatiana, Nakazawa Yuka, Mitsutake Norisato, Akulevich Natallia, Namba Hiroyuki, Yamashita Shunichi
Abstract excerpt
Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of cellular processes potentially influenced by THRs, we addressed the role of THRB (thyroid hormone receptor beta) in cellular radiosensitivity. Wild-type and...
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