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Article

Premature aging with impaired oxidative stress defense in mice lacking TR4.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2011

Lee Yi-Fen, Liu Su, Liu Ning-Chun, Wang Ruey-Sheng, Chen Lu-Min, Lin Wen-Jye, Ting Huei-Ju, Ho Hsin-Chiu, Li Gonghui, Puzas Edward J, Wu Qiao, Chang Chawnshang

Abstract excerpt

Early studies suggest that TR4 nuclear receptor is a key transcriptional factor regulating various biological activities, including reproduction, cerebella development, and metabolism. Here we report that mice lacking TR4 (TR4(-/-)) exhibited increasing genome instability and defective oxidative stress defense, which are associated with premature aging phenotypes. At the cellular level, we observed rapid cellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21521714
DOI: 10.1152/ajpendo.00701.2010
PMCID: PMC3129845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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