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Article

Thyroid Hormone Signaling and Homeostasis During Aging

1 Aug 2013

Abstract excerpt

Studies in humans and in animal models show negative correlations between thyroid hormone (TH) levels and longevity. TH signaling is implicated in maintaining and integrating metabolic homeostasis at multiple levels, notably centrally in the hypothalamus but also in peripheral tissues. The question is thus raised of how TH signaling is modulated during aging in different tissues. Classically, TH actions on...

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PMID: 23696256
DOI: 10.1210/er.2012-1056

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