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Article

A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes.

Genomics, proteomics & bioinformatics - 1 Feb 2014

Léger Hélène, Smet-Nocca Caroline, Attmane-Elakeb Amel, Morley-Fletcher Sara, Benecke Arndt G, Eilebrecht Sebastian

Abstract excerpt

The thymine DNA glycosylase (TDG) is a multifunctional enzyme, which is essential for embryonic development. It mediates the base excision repair (BER) of G:T and G:U DNA mismatches arising from the deamination of 5-methyl cytosine (5-MeC) and cytosine, respectively. Recent studies have pointed at a role of TDG during the active demethylation of 5-MeC within CpG islands. TDG interacts with the histone acetylase...

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Share to CREB-Binding Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Share to Receptors, Retinoic Acid

Share to Retinoic Acid Receptor alpha

Share to Transcription, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 24394593
DOI: 10.1016/j.gpb.2013.11.001
PMCID: PMC4411359

Genes

TDG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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