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Article

Structural requirements for the specific binding of CRABP2 to cyclin D3.

Structure (London, England : 1993) - 5 Dec 2024

Pastok Martyna W, Tomlinson Charles W E, Turberville Shannon, Butler Abbey M, Baslé Arnaud, Noble Martin E M, Endicott Jane A, Pohl Ehmke, Tatum Natalie J

Abstract excerpt

Cellular retinoic acid binding protein 2 (CRABP2) transports retinoic acid from the cytoplasm to the nucleus where it then transfers its cargo to retinoic acid receptor-containing complexes leading to activation of gene transcription. We demonstrate using purified proteins that CRABP2 is also a cyclin D3-specific binding protein and that the CRABP2 cyclin D3 binding site and the proposed CRABP2 nuclear...

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Identifiers

PMID: 39419021
DOI: 10.1016/j.str.2024.09.020

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