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Article

Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis.

Hepatology (Baltimore, Md.) - 1 Jun 2014

Tabibian James H, O'Hara Steven P, Splinter Patrick L, Trussoni Christy E, LaRusso Nicholas F

Abstract excerpt

UNLABELLED: Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown etiopathogenesis. Here we tested the hypothesis that cholangiocyte senescence is a pathophysiologically important phenotype in PSC. We assessed markers of cellular senescence and senescence-associated secretory phenotype (SASP) in livers of patients with PSC, primary biliary cirrhosis, hepatitis C, and in normals by...

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Source

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Identifiers

PMID: 24390753
DOI: 10.1002/hep.26993
PMCID: PMC4167827

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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