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Article

New concept: cellular senescence in pathophysiology of cholangiocarcinoma.

Expert review of gastroenterology & hepatology - 1 Jan 2016

Sasaki Motoko, Nakanuma Yasuni

Abstract excerpt

Cholangiocarcinoma, a malignant tumor arising in the hepatobiliary system, presents with poor prognosis because of difficulty in its early detection/diagnosis. Recent progress revealed that cellular senescence may be involved in the pathophysiology of cholangiocarcinoma. Cellular senescence is defined as permanent growth arrest caused by several cellular injuries, such as oncogenic mutations and oxidative stress....

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Identifiers

PMID: 26680649
DOI: 10.1586/17474124.2016.1133291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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