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Article

Structural basis of the ultrasensitive calcium indicator GCaMP6.

Science China. Life sciences - 1 Mar 2014

Ding JingJin, Luo Andrew F, Hu LiYan, Wang DaCheng, Shao Feng

Abstract excerpt

GCaMP is one of the most widely used calcium indicators in neuronal imaging and calcium cell biology. The newly developed GCaMP6 shows superior brightness and ultrasensitivity to calcium concentration change. In this study, we determined crystal structures of Ca(2+)-bound GCaMP6 monomer and dimer and presented detailed structural analyses in comparison with its parent version GCaMP5G. Our analyses reveal the...

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PMID: 24390420
DOI: 10.1007/s11427-013-4599-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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