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Article

Design and mechanistic insight into ultrafast calcium indicators for monitoring intracellular calcium dynamics.

Scientific reports - 6 Dec 2016

Helassa Nordine, Podor Borbala, Fine Alan, Török Katalin

Abstract excerpt

Calmodulin-based genetically encoded fluorescent calcium indicators (GCaMP-s) are powerful tools of imaging calcium dynamics from cells to freely moving animals. High affinity indicators with slow kinetics however distort the temporal profile of calcium transients. Here we report the development of reduced affinity ultrafast variants of GCaMP6s and GCaMP6f. We hypothesized that GCaMP-s have a common kinetic...

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Identifiers

PMID: 27922063
DOI: 10.1038/srep38276
PMCID: PMC5138832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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