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Article

Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics.

Scientific reports - 3 Nov 2015

Helassa Nordine, Zhang Xiao-hua, Conte Ianina, Scaringi John, Esposito Elric, Bradley Jonathan, Carter Thomas, Ogden David, Morad Martin, Török Katalin

Abstract excerpt

Faithful reporting of temporal patterns of intracellular Ca(2+) dynamics requires the working range of indicators to match the signals. Current genetically encoded calmodulin-based fluorescent indicators are likely to distort fast Ca(2+) signals by apparent saturation and integration due to their limiting fluorescence rise and decay kinetics. A series of probes was engineered with a range of Ca(2+) affinities and...

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Identifiers

PMID: 26527405
DOI: 10.1038/srep15978
PMCID: PMC4630588

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