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Article

MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2014

Bertsch Elizabeth, Qiang Wenan, Zhang Qing, Espona-Fiedler Margarita, Druschitz Stacy, Liu Yu, Mittal Khush, Kong Beihua, Kurita Takeshi, Wei Jian-Jun

Abstract excerpt

Recent identification of somatic MED12 mutations in most uterine leiomyomas brings a new venue for the study of the tumorigenesis of leiomyomas. We are particularly interested in the correlation of MED12 and HMGA2 gene products in leiomyomas and leiomyosarcomas with and without MED12 mutations. To address these issues, in this study we examined MED12 mutations in a large cohort of usual type leiomyomas (178...

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Source

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Identifiers

PMID: 24390224
DOI: 10.1038/modpathol.2013.243
PMCID: PMC4081525

Genes

MED12
HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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