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Article

HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas.

Gynecologic oncology - 1 Sept 2018

Galindo Luis Javier, Hernández-Beeftink Tamara, Salas Ana, Jung Yaiza, Reyes Ricardo, de Oca Francisco Montes, Hernández Mariano, Almeida Teresa A

Abstract excerpt

OBJECTIVE: Around 70% of uterine leiomyomas show MED12 mutations while overexpression of HMGA2 mRNA is also highly frequent in fibroids. However, previous studies suggested that alterations in both genes are mutually exclusive. In the present study, we searched for mutation in MED12 and analyzed the expression of HMGA2 in 20 uterine leiomyomas and their matched myometrium. METHODS: Normal and tumor tissue...

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Source

Identifiers

PMID: 30017537
DOI: 10.1016/j.ygyno.2018.07.007

Genes

HMGA2
MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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