Article
MED12 alterations in both human benign and malignant uterine soft tissue tumors.
PloS one - 1 Jan 2012
Pérot Gaëlle, Croce Sabrina, Ribeiro Agnès, Lagarde Pauline, Velasco Valérie, Neuville Agnès, Coindre Jean-Michel, Stoeckle Eberhard, Floquet Anne, MacGrogan Gaëtan, Chibon Frédéric
Abstract excerpt
The relationship between benign uterine leiomyomas and their malignant counterparts, i.e. leiomyosarcomas and smooth muscle tumors of uncertain malignant potential (STUMP), is still poorly understood. The idea that a leiomyosarcoma could derive from a leiomyoma is still controversial. Recently MED12 mutations have been reported in uterine leiomyomas. In this study we asked whether such mutations could also be...
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