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Article

Subtype-Specific Tumor-Associated Fibroblasts Contribute to the Pathogenesis of Uterine Leiomyoma.

Cancer research - 15 Dec 2017

Wu Xin, Serna Vanida A, Thomas Justin, Qiang Wenan, Blumenfeld Michael L, Kurita Takeshi

Abstract excerpt

Recent genomic studies have identified subtypes of uterine leiomyoma (LM) with distinctive genetic alterations. Here, we report the elucidation of the biological characteristics of the two most prevalent uterine leiomyoma subtypes, MED12-mutant (MED12-LM) and HMGA2-overexpressing (HMGA2-LM) uterine leiomyomas. Because each tumor carries only one genetic alteration, both subtypes are considered to be monoclonal....

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Share to Cancer-Associated Fibroblasts
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HMGA2 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 29055020
DOI: 10.1158/0008-5472.CAN-17-1744
PMCID: PMC6015476

Genes

MED12
HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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