Mutations in the D-channel of cytochrome c oxidase causes leakage of the proton pump.

Abstract excerpt

It has experimentally been found that certain mutations close to the entry point of the proton transfer channel in cytochrome c oxidase stop proton translocation but not the oxygen reduction chemistry. This effect is termed uncoupling. Since the mutations are 20Å away from the catalytic center, this is very surprising. A new explanation for this phenomenon is suggested here, involving a local effect at the entry...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Electron Transport Complex IV
• Share to Models, Molecular
• Share to Mutation