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Replacing Asn207 by aspartate at the neck of the D channel in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides results in decoupling the proton pump.

Biochemistry - 28 Nov 2006

Han Dan, Namslauer Andreas, Pawate Ashtamurthy, Morgan Joel E, Nagy Stanislav, Vakkasoglu Ahmet S, Brzezinski Peter, Gennis Robert B

Abstract excerpt

Cytochrome oxidase catalyzes the reduction of O2 to water and conserves the considerable free energy available from this reaction in the form of a proton motive force. For each electron, one proton is electrogenically pumped across the membrane. Of particular interest is the mechanism by which the proton pump operates. Previous studies of the oxidase from Rhodobacter sphaeroides have shown that all of the pumped...

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PMID: 17115701
DOI: 10.1021/bi061465q
PMCID: PMC2535581

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Replacing Asn207 by aspartate at the neck of the D channel in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides results in decoupling the proton pump.PMID 17115701Read ↗

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