Article
The D-channel of cytochrome oxidase: an alternative view.
Biochimica et biophysica acta - 1 Oct 2011
Wikström Mårten, Verkhovsky Michael I
Abstract excerpt
The D-pathway in A-type cytochrome c oxidases conducts protons from a conserved aspartate on the negatively charged N-side of the membrane to a conserved glutamic acid at about the middle of the membrane dielectric. Extensive work in the past has indicated that all four protons pumped across the membrane on reduction of O(2) to water are transferred via the D-pathway, and that it is also responsible for transfer...
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