Article
On the role of the K-proton transfer pathway in cytochrome c oxidase.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2001
Brändén M, Sigurdson H, Namslauer A, Gennis R B, Adelroth P, Brzezinski P
Abstract excerpt
Cytochrome c oxidase is a membrane-bound enzyme that catalyzes the four-electron reduction of oxygen to water. This highly exergonic reaction drives proton pumping across the membrane. One of the key questions associated with the function of cytochrome c oxidase is how the transfer of electrons and protons is coupled and how proton transfer is controlled by the enzyme. In this study we focus on the function of...
Topics
- Amino Acid Substitution
- Binding Sites
- Biological Transport
- Electron Transport
- Electron Transport Complex IV
- Electrons
- Heme
- Hydrogen Bonding
- Lysine
- Models, Molecular
- Mutation
- Oxygen
- Photolysis
- Protein Conformation