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Article

Mechanism and energetics by which glutamic acid 242 prevents leaks in cytochrome c oxidase.

Biochimica et biophysica acta - 1 Oct 2009

Kaila Ville R I, Verkhovsky Michael I, Hummer Gerhard, Wikström Mårten

Abstract excerpt

Cytochrome c oxidase (CcO) is the terminal enzyme of aerobic respiration. The energy released from the reduction of molecular oxygen to water is used to pump protons across the mitochondrial or bacterial membrane. The pump function introduces a mechanistic requirement of a valve that prevents protons from flowing backwards during the process. It was recently found that Glu-242, a key amino acid in transferring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19406098
DOI: 10.1016/j.bbabio.2009.04.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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