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Article

Where is 'outside' in cytochrome c oxidase and how and when do protons get there?

Biochimica et biophysica acta - 12 May 2000

Mills D A, Florens L, Hiser C, Qian J, Ferguson-Miller S

Abstract excerpt

Cytochrome c oxidase moves both electrons and protons in its dual role as a terminal electron acceptor and a contributor to the proton motive force which drives the formation of ATP. Although the sequence of electron transfer events is well-defined, the correlated mechanism and routes by which protons are translocated across the membrane are not. A recent model [Michel, Proc. Natl. Acad. Sci. USA 95 (1998) 12819]...

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PMID: 10812032
DOI: 10.1016/s0005-2728(00)00067-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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