Article
The MYO9B gene is a strong risk factor for developing refractory celiac disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Dec 2007
Wolters Victorien M, Verbeek Wieke H M, Zhernakova Alexandra, Onland-Moret Charlotte, Schreurs Marco W J, Monsuur Alienke J, Verduijn Willem, Wijmenga Cisca, Mulder Chris J J
Abstract excerpt
BACKGROUND & AIMS: Celiac disease (CD) is associated with HLA-DQ2 and HLA-DQ8 and has been linked to genetic variants in the MYO9B gene on chromosome 19. HLA-DQ2 homozygosity is associated with complications of CD such as refractory celiac disease type II (RCD II) and enteropathy-associated T-cell lymphoma (EATL). We investigated whether MYO9B also predisposes to RCD II and EATL. METHODS: Genotyping of MYO9B and...
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