Article
Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma.
Scandinavian journal of gastroenterology - 1 Dec 2012
Menke Vivianda, Van Zoest Katinka P M, Moons Leon M G, Pot Raymond G J, Siersema Peter D, Kuipers Ernst J, Kusters Johannes G
Abstract excerpt
BACKGROUND: Reflux esophagitis (RE) and Barrett's esophagus (BE) are predisposing factors for development of esophageal adenocarcinoma (EAC), the solid tumor with the fastest rising incidence in the Western world. This RE-BE-EAC cascade involves multiple host factors and consequently multiple genes. Polymorphisms in the 3' region of myosin IXB (Myo9B) are associated with chronic inflammatory gastrointestinal...
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