Article
ERBB2 in cat mammary neoplasias disclosed a positive correlation between RNA and protein low expression levels: a model for erbB-2 negative human breast cancer.
PloS one - 1 Jan 2013
Santos Sara, Baptista Cláudia S, Abreu Rui M V, Bastos Estela, Amorim Irina, Gut Ivo G, Gärtner Fátima, Chaves Raquel
Abstract excerpt
Human ERBB2 is a proto-oncogene that codes for the erbB-2 epithelial growth factor receptor. In human breast cancer (HBC), erbB-2 protein overexpression has been repeatedly correlated with poor prognosis. In more recent works, underexpression of this gene has been described in HBC. Moreover, it is also recognised that oncogenes that are commonly amplified or deleted encompass point mutations, and some of these...
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