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Article

The c-erbB-2 Protein in Oncogenesis: Molecular Structure to Molecular Epidemiology

1 Jan 1994

Abstract excerpt

The c-erbB-2 (HER-2, neu) oncogene has been implicated frequently in many human tumors. This oncogene codes for a 185-kDa protein that functions as a transmembrane growth factor receptor. Overexpression of the normal protein or point mutations in the transmembrane domain of the protein have been shown to have a transforming effect. Molecular structure studies of the transmembrane domain provide a plausible...

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PMID: 7849090
DOI: 10.1615/critrevoncog.v5.i2-3.100

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