Article
Sequence variants and haplotype analysis of cat ERBB2 gene: a survey on spontaneous cat mammary neoplastic and non-neoplastic lesions.
International journal of molecular sciences - 1 Jan 2012
Santos Sara, Bastos Estela, Baptista Cláudia S, Sá Daniela, Caloustian Christophe, Guedes-Pinto Henrique, Gärtner Fátima, Gut Ivo G, Chaves Raquel
Abstract excerpt
The human ERBB2 proto-oncogene is widely considered a key gene involved in human breast cancer onset and progression. Among spontaneous tumors, mammary tumors are the most frequent cause of cancer death in cats and second most frequent in humans. In fact, naturally occurring tumors in domestic animals, more particularly cat mammary tumors, have been proposed as a good model for human breast cancer, but critical...
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