Article
Increased survival in dogs with malignant mammary tumours overexpressing HER-2 protein and detection of a silent single nucleotide polymorphism in the canine HER-2 gene.
Veterinary journal (London, England : 1997) - 1 Apr 2009
Hsu Wei-Li, Huang Hui-Min, Liao Jiunn-Wang, Wong Min-Liang, Chang Shih-Chieh
Abstract excerpt
The aims of this study were to explore the relationship between clinical outcome and HER-2 protein expression in dogs with malignant mammary tumours after surgery and to determine the sequence of the HER-2 gene. Tissues from 91 dogs diagnosed with malignant mammary tumours, six with benign lesions and two normal mammary glands were analysed for the expression of HER-2 by immunohistochemistry (IHC). Exons 14-18 of...
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