Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations of the c-erbB2 gene in human breast cancer.

Journal of cancer research and clinical oncology - 1 Jan 1992

Zoll B, Kynast B, Corell B, Marx D, Fischer G, Schauer A

Abstract excerpt

DNA amplification, RNA overexpression and p185 protein expression of the c-erbB2 oncogene were investigated in 109 cases of breast cancer with the aim of evaluating any correlation between the different methods. A correlation between Southern blotting and immunohistochemical analysis of paraffin-embedded material was found. Thus, amplification of the c-erbB2 oncogene leads to overexpression of the p185 protein....

Topics

Base Sequence
Biomarkers, Tumor
Breast Neoplasms
DNA, Neoplasm
Female
Humans
Molecular Sequence Data
Mutation
Neoplasm Staging
Oligodeoxyribonucleotides
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogenes

Receptor, ErbB-2

Receptors, Estrogen

Source

Identifiers

PMID: 1352298
DOI: 10.1007/BF01629432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1352298-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations of the c-erbB2 gene in human breast cancer.PMID 1352298Read ↗

ERBB2 in cat mammary neoplasias disclosed a positive correlation between RNA and protein low expression levels: a model for erbB-2 negative human breast cancer.Semantic proximity Read ↗

The c-erbB-2 Protein in Oncogenesis: Molecular Structure to Molecular EpidemiologySemantic proximity Read ↗

Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer.Semantic proximity Read ↗

Role of HER2 gene overexpression in breast carcinomaSemantic proximity Read ↗

Expression of the p185 encoded by her2 oncogene in normal and transformed human tissuesSemantic proximity Read ↗

Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein statusSemantic proximity Read ↗

Increased expression of c-erbB-2 in hormone-dependent breast cancer cells inhibits cell growth and induces differentiation.Semantic proximity Read ↗

Low frequency of ErbB-2 proto-oncogene overexpression in human leukocyte antigen-A2-positive breast cancer patients.Semantic proximity Read ↗

Optimization of immunohistochemical detection of ERBB2 in human breast cancer: Impact of fixationSemantic proximity Read ↗

Mutations in transmembrane domain of c-erbB-2 gene in human malignant tumours of the central nervous system.Semantic proximity Read ↗

c-erbB2 and topoisomerase IIα protein expression independently predict poor survival in primary human breast cancer: a retrospective studySemantic proximity Read ↗

<i>mdm2</i> gene alterations and mdm2 protein expression in breast carcinomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.