Article
Alterations of the c-erbB2 gene in human breast cancer.
Journal of cancer research and clinical oncology - 1 Jan 1992
Zoll B, Kynast B, Corell B, Marx D, Fischer G, Schauer A
Abstract excerpt
DNA amplification, RNA overexpression and p185 protein expression of the c-erbB2 oncogene were investigated in 109 cases of breast cancer with the aim of evaluating any correlation between the different methods. A correlation between Southern blotting and immunohistochemical analysis of paraffin-embedded material was found. Thus, amplification of the c-erbB2 oncogene leads to overexpression of the p185 protein....
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