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Article

Altered promoter usage characterizes monoallelic transcription arising with ERBB2 amplification in human breast cancers.

Genes, chromosomes & cancer - 1 Nov 2006

Benz Christopher C, Fedele Vita, Xu Fan, Ylstra Bauke, Ginzinger David, Yu Mamie, Moore Dan, Hall Rayna Kneuper, Wolff Daynna J, Disis Mary L, Eppenberger-Castori Serenella, Eppenberger Urs, Schittulli Francesco, Tommasi Stefania, Paradiso Angelo, Scott Gary K, Albertson Donna G

Abstract excerpt

Analysis of a collection of human breast cancers (n = 150), enriched in ERBB2-positive cases (n = 57) and involving tumor genotyping relative to population-matched blood genotyping (n = 749) for a common ERBB2 single nucleotide polymorphism Ala(G)1170Pro(C), revealed that ERBB2 amplification in breast cancer is invariably monoallelic. Analysis of paired breast cancer and blood samples from informative (G1170C...

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Source

Identifiers

PMID: 16883574
DOI: 10.1002/gcc.20364

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered promoter usage characterizes monoallelic transcription arising with ERBB2 amplification in human breast cancers.PMID 16883574Read ↗

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