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Article

The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk.

Carcinogenesis - 1 Mar 2005

Frank Bernd, Hemminki Kari, Wirtenberger Michael, Bermejo Justo Lorenzo, Bugert Peter, Klaes Rüdiger, Schmutzler Rita K, Wappenschmidt Barbara, Bartram Claus R, Burwinkel Barbara

Abstract excerpt

Overexpression of the proto-oncogene ERBB2 (HER2/NEU) has been observed in 20-30% of breast cancers involving poor prognosis. Genetic alterations within ERBB2 have been shown to induce carcinogenesis and metastasis. We investigated eight annotated single nucleotide polymorphisms for occurrence in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15550452
DOI: 10.1093/carcin/bgh342

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15550452-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk.PMID 15550452Read ↗

655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations.Semantic proximity Read ↗

Polymorphisms of ERBB2 and breast cancer risk: a meta-analysis of 26 studies involving 35,088 subjects.Semantic proximity Read ↗

HER2 Ile655Val polymorphism contributes to breast cancer risk: evidence from 27 case-control studies.Semantic proximity Read ↗

The erbB2/HER2/neu receptor polymorphism Ile655Val and breast cancer risk.Semantic proximity Read ↗

Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies.Semantic proximity Read ↗

A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer.Semantic proximity Read ↗

HER2 Codon 655 (Ile/Val) Polymorphism and Breast Cancer in Austrian Women.Semantic proximity Read ↗

HER2 Codon 655 (Ile/Val) Polymorphism and Breast Cancer in Austrian Women.Semantic proximity Read ↗

HER-2/neu Ile655Val polymorphism and the risk of breast cancer.Semantic proximity Read ↗

Updated meta-analysis on HER2 polymorphisms and risk of breast cancer: evidence from 32 studies.Semantic proximity Read ↗

Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk.Semantic proximity Read ↗

Functional Common and Rare ERBB2 Germline Variants Cooperate in Familial and Sporadic Cancer Susceptibility.Semantic proximity Read ↗

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